ESTRO 2024 - Abstract Book

S948

Clinical - CNS

ESTRO 2024

Fractionated proton radiotherapy appears to be suitable for the treatment of schwannomas of various anatomical origin. Our data suggest acceptable preservation of nerve function with normofractionated proton radiotherapy. Appropriate patient selection is essential to identify the patients who benefit most from proton radiotherapy.

Keywords: schwannoma, proton radiotherapy

References:

1: Thai NLB, Mai NY, Vuong NL, et al. Treatment for vestibular schwannoma: Systematic review and single arm meta analysis. Am J Otolaryngol. 2022 Mar-Apr;43(2):103337. doi: 10.1016/j.amjoto.2021.103337.

2: Kessel KA, Fischer H, Vogel MM, et al. Fractionated vs. single-fraction stereotactic radiotherapy in patients with vestibular schwannoma: Hearing preservation and patients' self-reported outcome based on an established questionnaire. Strahlenther Onkol. 2017 Mar;193(3):192-199. English. doi: 10.1007/s00066-016-1070-0.

3: House JW, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg. 1985 Apr;93(2):146-7. doi: 10.1177/019459988509300202.

2792

Digital Poster

Salvage fractionated radiotherapy for large pituitary adenomas: a mono-institutional analysis

marco castellano 1,2 , Andrei Fodor 1 , Giorgio Purrello 1,2 , Chiara Lucrezia Deantoni 1 , Francesca Maddaloni 3 , Stefano Arcangeli 2 , Nadia Di Muzio 1,4 1 IRCCS San Raffaele Scientific Institute, Department of Radiation Oncology, Milan, Italy. 2 Milan Bicocca University, School of Radiation Oncology, Milan, Italy. 3 IRCCS San Raffaele Scientific Institute, Medical Physics, Milan, Italy. 4 Vita Salute San Raffaele University, School of Medicine and Surgery, Milan, Italy

Purpose/Objective:

Pituitary adenomas are generally treated in our institution with Gamma Knife (GK) radiosurgery (SRS), with good results [1]. In case of large pituitary adenomas or in proximity of optic pathways [2], patients are referred to fractionated radiotherapy (FRT). In this study we evaluate the safety and efficacy of treatments performed with alternative radiation techniques other than GK for large adenomas, when there is a significant risk that the dose to optical structures might exceed its tolerance.

Material/Methods: