ESTRO 2024 - Abstract Book

S966

Clinical - CNS

ESTRO 2024

Detailed comparison of radiation plans using Proknow was easily applicable and instantly allows for quality control by comparing variations in target volume and normal tissue exposure individually and in comparison to the whole cohort.

Keywords: glioblastoma, CeTeG, plan comparison

References:

1 Herrlinger U, Tzaridis T, Mack F, et al. Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Lancet. Feb 16 2019;393(10172):678-688. doi:10.1016/s0140-6736(18)31791-4

3135

Digital Poster

Long-Term Results of LINAC-Based Radiosurgery for Pediatric Intracranial Arteriovenous Malformation

Ahmed Gawish 1,2 , Fabian Eberle 1,2 , Markus Schymalla 1,2 , Rita Engenhart-Cabillic 1,2 , Luis Mohr 1 , Hilke Vorwerk 1,2 , Sebastian Adebrg 1,2 1 University Hospital Marburg, Radiation oncology, Marburg, Germany. 2 Marburg Ion-Beam Therapy Center, Radiation oncology, Marburg, Germany

Purpose/Objective:

This study seeks to elucidate the long-term results associated with linear accelerator (LINAC)-based radiosurgery (SRS) treatment of intracranial arteriovenous malformations (AVM) in children.

Material/Methods:

Our retrospective analysis comprises 20 children (18 years and under) treated from 2002 to 2022. Every patient underwent single-fraction LINAC-based SRS, receiving a median dose of 19 Gy (ranging from 14-20 Gy) targeting the 80% isodose curve. The median age at the time of treatment was 14 years, with ages spanning from 5 to 18 years. The median AVM volume was measured at 1.55 mL, with a range between 0.8 and 4 mL. The median score, based on a modified radiosurgery-centric AVM scale, was 0.83 (ranging from 0.18 to 2.96). Intracranial hemorrhage was the predominant initial symptom, observed in 12 out of the 20 cases. Before undergoing LINAC-based radiosurgery, 11 patients had interventions, including previous embolizations or resections. Four AVMs were located in critical regions, namely the basal ganglia, thalamus, or brainstem. Obliteration was validated using cerebral angiography.