ESTRO 2024 - Abstract Book

S990

Clinical - Gynaecology

ESTRO 2024

the planned PTV45 had a mean volume of 979.66 cc ± 107.98 cc, while the adapted PTV45 volume measured 954.57 cc ± 105.02 cc, reflecting an average reduction from the planned PTV of 2.54% ± 0.02%. The planned PTV55 had a mean volume of 18.21 cc ± 9.58 cc, and the adapted PTV55 volume was 12.86 cc ± 4.12 cc, representing an average reduction from the planned PTV of 27.30% ± 6.14%. The PTV dose D95% was achieved at 97.16%±2.22% of the prescription dose. The bowel dose metrics showcased a V30Gy at 363.75 ± 102.93 cc and a V40Gy at 189.65 ± 75.97 cc. The average duration of a treatment session was 20 minutes and 5 seconds. The patients' quality of life and oncological outcomes are currently under investigation.

Conclusion:

In our phase II trial for locally advanced cervical cancer, the integration of ART effectively tailored radiation doses based on daily anatomical variations. Preliminary results showed a notable reduction in acute GI toxicity and precise dosimetry outcomes, emphasizing ART’s potential to enhance treatment safety and efficacy.

Keywords: Adaptive radiotherapy, cervical cancer, AI

References:

1. Mell LK, Sirák I, Wei L, Tarnawski R, Mahantshetty U, Yashar CM, McHale MT, Xu R, Honerkamp-Smith G, Carmona R, Wright M, Williamson CW, Kasaová L, Li N, Kry S, Michalski J, Bosch W, Straube W, Schwarz J, Lowenstein J, Jiang SB, Saenz CC, Plaxe S, Einck J, Khorprasert C, Koonings P, Harrison T, Shi M, Mundt AJ; INTERTECC Study Group. Bone Marrow-sparing Intensity Modulated Radiation Therapy With Concurrent Cisplatin For Stage IB-IVA Cervical Cancer: An International Multicenter Phase II Clinical Trial (INTERTECC-2). Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):536-545. doi: 10.1016/j.ijrobp.2016.11.027. Epub 2016 Nov 23. PMID: 28126303.

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Neoadjuvant Radiation in Locally Advanced Endometrial Cancer: A Single Institution Outcomes

John Michael P. Tomagan 1 , Charles Cedy C. Lo 1 , Alyssa Anne E. Granda 1 , Mae Mullet Panaligan 2 , Candice Chin-chin C. Yu 1 , Veronica T. Vera Cruz 1 1 Jose R. Reyes Memorial Medical Center, Department of Radiotherapy, Manila, Philippines. 2 Jose R. Reyes Memorial Medical Center, Department of Obstetrics and Gynecology, Section of Gynecologic Oncology and Trophoblastic Disease, Manila, Philippines

Purpose/Objective:

Endometrial cancer management in cases with suspected or gross cervical involvement lacks a defined standard of care. We assessed the outcomes of locally advanced endometrial cancer patients with cervical and/or parametrial involvement treated with neoadjuvant radiation followed by hysterectomy.

Material/Methods: