ESTRO 2025 - Abstract Book

S1032

Clinical – Head & neck

ESTRO 2025

Conclusion: Including mean dose to the MO was consistently associated with improved model performance compared to models including dose to the PCM or both regions. The model’s confidence interval further suggest it is best model for predicting dysphagia in our cohort (Figure 1). These results add to the growing body of evidence that suggest new dose limits for the MO during head and neck cancer radiotherapy should be further investigated.

Keywords: Head & neck, dysphagia measures, medulla oblongata

References: 1.

Denaro, N., M.C. Merlano, and E.G. Russi, Dysphagia in Head and Neck Cancer Patients: Pretreatment Evaluation, Predictive Factors, and Assessment during Radio-Chemotherapy, Recommendations. Clin Exp Otorhinolaryngol, 2013. 6(3): p. 117-26. 2. Duprez, F., et al., Systematic review of dose--volume correlates for structures related to late swallowing disturbances after radiotherapy for head and neck cancer. Dysphagia, 2013. 28(3): p. 337-49. 3. Vasquez Osorio, E., et al., Dysphagia at 1 Year is Associated With Mean Dose to the Inferior Section of the Brain Stem. Int J Radiat Oncol Biol Phys, 2023. 117(4): p. 903-913.

Acknowledgment These authors contributed equally to this work: Eliana M Vasquez Osorio, Isabella Fornacon-Wood.