ESTRO 2025 - Abstract Book

S1078

Clinical – Head & neck

ESTRO 2025

Results:

The model has achieved visually pleasing performance. As can be seen from Figure 2, compared to other five comparative multimodal segmentation models, our proposed model has generated GTV most similar to the clinical ground truth. Quantitively analysis by Dice similarity coefficients(DSC) and Jaccard index(JI) were also operated, and the proposed model has reached a mean DSC(/%) of 78.27±8.67(average), 81.29±7.33(GTVp), 75.25±10.01(GTVnd), and a mean JI(/%) of 65.23±9.02(average), 67.79±7.66(GTVp), 62.66±10.38(GTVnd). Conclusion: We developed a performant Multimodal Nasopharyngeal Carcinoma Segmentation model by selective information extraction technique based on 3D gaussian representations and step-wise coarse-to-fine segmentation process based on 3D-Gaussian-prompted Diffusion Deep Learning Model. The accurate GTV segmentation performance and interpretable generating process of our prosed model have formed a reliable clinical solution for NPC GTV auto delineation, which may further facilitate more accurate NPC treatment planning.

Keywords: Multi-Modal Segmentation, Deep Learning

References: International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma. Anne et.al. Green journal.2018

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Mini-Oral Patterns of failure after radiotherapy for nasopharyngeal carcinoma in a low-incidence population: A national DAHANCA analysis (Denmark, 2000-2018) Anne Marie Lindegaard 1 , Katrin Håkansson 1 , Maria Andersen 2 , Mogens Bernsdorf 1 , Jesper G Eriksen 3 , Mohammad Farhadi 4 , Lisa L Hjalgrim 5 , Kenneth Jensen 6 , Jørgen Johansen 7 , Christian Maare 8 , Jens Overgaard 9 , Christina C Plaschke 10 , Erik Schiess 1 , Jeppe Friborg 1 1 Department of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 2 Department of Oncology, Aalborg University Hospital, Aalborg, Denmark. 3 Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. 4 Department of Oncology, Zealand University Hospital, Naestved, Denmark. 5 Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 6 Danish Center of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark. 7 Department of Oncology, Odense University Hospital, Odense, Denmark. 8 Department of Oncology, Copenhagen University Hospital – Herlev and