ESTRO 2025 - Abstract Book

S1105

Clinical – Head & neck

ESTRO 2025

Conclusion: Our data define the combination of RT-induced cGAS re-localization and systemic type I interferon activity as potential predictors of RT responsiveness in HNSCC patients. This knowledge will help design HNSCC RT treatment protocols aimed at maximizing immune stimulation, particularly when combined with immunotherapy.

Keywords: HNSCC, cGAS/STING,

References: 1. Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.D., Mauceri, H., Beckett, M et al.STING-Dependent Cytosolic DNA Sensing promotes Radiation-Induced Type I Interferon Dependent Antitumor Immunity in Immunogenic Tumors. Immunity . 2014; 41 ( 843). 2. Mekers VE, Kho VM, Ansems M, and Adema GJ. cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity. Radiother Oncol. 2022;174:158. 3. Sprooten J, Vankerckhoven A, Vanmeerbeek I, Borras DM, Berckmans Y, Wouters R, et al. Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer. J Immunother Cancer. 2021;9(11).

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Digital Poster Surgery versus radiotherapy in T2N0 laryngeal cancer: A unicentric retrospective study Nicolas Deny 1 , Diana Mitrea 2 , Yungan TAO 3 , France Nguyen 3 , Philippe Gorphe 3 , Ingrid Breuskin 3 , Stéphane Temam 3 , Camélia Billard-Sandu 3 , Caroline Even 3 , Pierre Blanchard 3 , Roger Sun 3 1 Radiation oncology, Centre hospitalier, Limoges, France. 2 Radiation oncology, Centre Antoine Lacassagne, Nice, France. 3 Radiation oncology, Gustave Roussy, Villejuif, France

Purpose/Objective: Surgery and radiotherapy have long been effective for early-stage laryngeal cancers, each offering distinct advantages and