ESTRO 2025 - Abstract Book

S1250

Clinical – Lower GI

ESTRO 2025

Conclusion: Patients with LARC treated with standard treatment tend to improve anorectal function with rehabilitative therapy. Radiotherapy dose to the anal sphincter is crucial for predicting rehabilitation success, with higher doses associated with a higher risk of failure. Adjuvant chemotherapy negatively impacts rehabilitation, likely due to treatment timing. Extended rehabilitation duration tends to yield better outcomes. This may be considered to personalize cancer treatments and subsequent care.

Keywords: Rectal cancer, anal sphincter, anorectal function

References: Arias,F. Eito, C. Asín G. Fecal incontinence and radiation dos on anal sphincter in patients with locally advanced rectal cáncer (LARC) tretated with preoperative chemoradiotherapy: a restrospectivoe, single-institutional study. Clinical & translational Oncology, 2017 19(8), 969-975

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Digital Poster Role of surgery in the survival of rectal cancer after neoadjuvant chemoradiotherapy in patients without complete clinical response Romina Abyaneh 1 , Kasra Kolahdouzan 2 , Mohammad Babaei 1 , Mahdi Aghili 2 , Reza Ghalehtaki 2 1 Radiation Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of. 2 Department of Radiation Oncology, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of Purpose/Objective: Chemoradiotherapy (CRT) usually is the first step for treatment of locally advanced rectal cancer (LARC). Due to dramatic relief of symptoms after chemoradiotherapy some patients are reluctant to undergo surgery. We aimed to evaluate the outcomes of patients who did not undergo surgery after chemoradiotherapy. Material/Methods: In this retrospective cohort study we explored our database of rectal cancer patients treated between 2008 and 2019 at Cancer Institute of Iran. Our inclusion criteria were pathologically proven non-metastatic LARC and undergoing CRT before surgery. Those patients with a confirmed complete clinical response (by endoscopy and MRI) were excluded. We found 31 patients who did not undergo surgery at all after CRT (non-surgical group), and had at least one-month follow-up. We matched two controls (62 total) for each patients out of resected patients' cohort to from our surgical group. Our matching was based on clinical T and N stage and the distance from anal verge, age and sex. We used appropriate analytical tests to compare the overall survival between non-surgical and surgical group.