ESTRO 2025 - Abstract Book

S1261

Clinical – Lower GI

ESTRO 2025

3871

Digital Poster Anal Cancer Survivorship: A Comprehensive Evaluation Using Patient-Reported Outcomes (PROs) (ClinicalTrials.gov NCT06364579) Natalia Barogi 1 , Stefania Manfrida 1 , Diana Giannarelli 2 , Viola De Luca 1 , Bruno Fionda 1 , Roberta Bertolini 1 , Giuditta Chiloiro 1 , Vincenzo Frascino 1 , Luca Tagliaferri 1 , Maria Antonietta Gambacorta 1 1 Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 2 Facility of Epidemiology and Biostatistics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy Purpose/Objective: IMRT-based chemoradiation (CRT) improves tumor control and reduces acute toxicities in anal squamous cell carcinoma (ACC), but late toxicity remains a significant burden. This study evaluates long-term quality of life (QoL) using the Italian EORTC QLQ-C30 (cancer specific) and QLQ-ANL27 (site-specific) QoL questionnaire alongside clinician-reported outcomes (CROs) Material/Methods: Survivors from squamous cell ACC treated by RCT who had ended radiotherapy for at least one year were analyzed. (ClinicalTrials.gov NCT06364579). Data collected through the questionnaires were initially analyzed by the usual descriptive statistical techniques and then summarized as means and standard deviations. Associations with patient-related demographic and clinical variables were be studied by analysis of variance or Student's t test. Results: 78 pts were analyzed with a median follow-up of 43 months. The QLQ-C30 revealed high physical functioning (PF: 84.8 SD 16.7) and global QoL (74.1 SD 16). Fatigue (23 SD 21.86) and sleep disturbances (18.6 SD 23.8) were the most common symptoms. Single-item symptom scales in the QLQ-ANL27 highlighted challenges related to need of cleaning one-self more often (CL: 22.8 SD 27.8), to be close to a toilet (WC: 19.0 SD 28.8) and planning activities (PL: 17.1 SD 29.8). Sexual inactivity was reported by 73.08% of patients, with 41% indicating a significant impact on their sex life. At univariate analysis GI toxicity significantly correlated with bowel symptoms (p < 0.001), anal pain/discomfort (PA p = 0.003), CL (p < 0.001), and PL (p = 0.03). Patients with mild late GI toxicity (