ESTRO 2025 - Abstract Book

S1267

Clinical – Lower GI

ESTRO 2025

Conclusion: Based on our results, cCT strategy seems favorable regarding iCT because provides better pathological outcome after surgery, with similar postoperative complications and less acute toxicity. In terms of survival, we did not find any statistically significant differences, however, it seems that the possibility of recurrence is lower in this subgroup. On the other hand, in the induction group, intra-treatment progression were observed in 9%; so intra-treatment reevaluations should be protocolized to identify the subgroup of non-responders and lead the therapeutic approach.

Keywords: Rectal cancer, TNT

References: - Kang, M. K. . Implications of recent neoadjuvant clinical trials on the future practice of radiotherapy in locally advanced rectal cancer. World journal of gastroenterology: WJG, (2023) 29(6), 1011–1025. - Lo Greco, M. C., La Rocca, M., Marano. Integrated intensified chemoradiation in the setting of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer: A retrospective single-arm study on feasibility and efficacy. Cancers, (2023) 15(3), 921.