ESTRO 2025 - Abstract Book

S1273

Clinical – Lower GI

ESTRO 2025

The 5 years LC and DFS results were, for LLN+, 77% and 43% versus, for LLN-, 87% and 45%, respectively. Regarding the post-treatment analysis, in the group of patients with yLLNs+, we registered a significant statistical difference in LC with p-value=0.04 (fig 2). The 5 years LC results were, for yLLN+, 58% versus, for yLLN-, 87%. No statistical difference for DFS in post-treatment LLN.

Conclusion: In our experience, worse LC and DFS were correlated to the presence of LLNs both before and after CRT, confirming the hypothesis of their involvement in the progression of LARC. The prognostic value of LLN could be considered for LARC patients sub-group detection who could benefit from an intensified personalized approach.

Keywords: rectal cancer, lateral lymph nodes

References: 1. Ogura A, et al. ; Lateral Node Study Consortium. Lateral Nodal Features on Restaging Magnetic Resonance Imaging Associated With Lateral Local Recurrence in Low Rectal Cancer After Neoadjuvant Chemoradiotherapy or Radiotherapy. JAMA Surg. 2019 Sep 1;154(9):e192172. doi: 10.1001/jamasurg.2019.2172. Epub 2019 Sep 18. PMID: 31268504; PMCID: PMC6613303. 2. Sluckin TC, et al. Lateral Lymph Nodes in Rectal Cancer: Do we all Think the Same? A Review of Multidisciplinary Obstacles and Treatment Recommendations. Clin Colorectal Cancer. 2022 Jun;21(2):80-88. doi: 10.1016/j.clcc.2022.02.002. Epub 2022 Feb 19. PMID: 35339391.

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Digital Poster Survival Analysis and Prognostic Factors in Rectal Cancer treated with Hypofractionated Radiotherapy: Real World impact of Total Neoadjuvant Therapy. Maria del Carmen Herrera del Valle 1 , Ricardo Andrés Oyarzun Silva 1 , Laura Diaz Gómez 1 , Pablo Hernández Hernández 2 , Javier Jaén Olasolo 1,3