ESTRO 2025 - Abstract Book

S1295

Clinical - Lung

ESTRO 2025

inter-fraction robustness of clinical target volume (CTV) coverage, were compared using Friedman’s ANOVA, with Benjamini-Hochberg-adjusted post-hoc Wilcoxon tests if an overall difference between groups was found.

Results: Figure 1 shows the ∆NTCP calculated by subtracting the NTCP of IMPT from those of sPAT and dPAT, respectively. Both PAT techniques had significantly lower NTCP for mortality (P<0.001), pneumonitis (P<0.001), and oesophagitis (P<0.001), compared to IMPT. dPAT had lower NTCP for pneumonitis compared to sPAT (P=0.002). Based on Figure 1 , cumulative ∆NTCP versus IMPT varied between patients. Average and cumulative inter-fraction robustness of the CTV for the three planning techniques are shown in Figure 2 . Average inter-fraction robustness was slightly, but non-significantly, better for IMPT (P=0.051), while cumulative inter-fraction robustness was comparable between groups (P=0.87).

Figure 1. ∆NTCP for sPAT/dPAT versus IMPT