ESTRO 2025 - Abstract Book

S1318

Clinical - Lung

ESTRO 2025

The incidence of INF in stage III NSCLC patients treated predominantly with PT is 2.1%, comparable to rates in 3DCRT and IMRT cohorts.

Keywords: Isolated nodal failure, proton therapy, NSCLC

References: 1. Martinussen, H. M. A. et al. Is selective nodal irradiation in non-small cell lung cancer still safe when using IMRT? Results of a prospective cohort study. Radiotherapy and Oncology 121, 322–327 (2016). 2. De Ruysscher, D. et al. Selective mediastinal node irradiation based on FDG-PET scan data in patients with non small-cell lung cancer: A prospective clinical study. Int J Radiat Oncol Biol Phys 62, 988–994 (2005). 3. Langendijk, J. A. et al. Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach. Radiotherapy and Oncology vol. 107 267–273.

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Digital Poster Resting heart rate elevation and implications for autonomic dysfunction during and after concurrent chemo-radiotherapy in non-small cell lung cancer Ali Ajdari 1 , Alissa Cooper 2 , Rachel B Jimenez 1 , Florence (Katie) Keane 3 1 Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, USA. 2 Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. 3 Radiation Oncology, Massachusetts, Boston, USA Purpose/Objective: Disruption to the heart’s normal rate and rhythm is an understudied complication associated with radiation exposure to the heart, with potentially serious implications for patients’ exercise tolerance, quality of life, and cardiovascular health after thoracic radiotherapy [1-3]. Our objective is to longitudinally study the incidence and pattern of heart rate (HR) elevation in non-small cell lung cancer (NSCLC) patients undergoing definitive chemo-RT (CRT).