ESTRO 2025 - Abstract Book

S1326

Clinical - Lung

ESTRO 2025

Conclusion: The breathing score significantly correlates with local failure in patients treated with SBRT for lung and liver metastases. Lower scores are associated with worse outcomes and less stable breathing patterns, identifying patients with high-risk of local failure. Utilizing early-session data, the score offers potential for risk assessment to guide interventions in subsequent fractions and supports risk stratification in follow-up care.

Keywords: Breathing Score, Irregularity, Risk Stratification

1592

Digital Poster Immune checkpoint inhibition alters patterns of failure in inoperable stage III Non-Small Cell Lung Cancer patients treated with chemoradiotherapy Julian Taugner 1 , Silja Stamer 1 , Kerstin Hofstetter 2 , Chukwuka Eze 2 , Lukas Käsmann 2 , Alina Tenev 1 , Philipp Hartig 1 , Werner Spengler 3 , Thorben Groß 3 , Farkhad Manapov 4 , Claus Belka 2 , Maximilian Niyazi 1 1 Department of Radiation Oncology, UKT Universityhospital Tuebingen, Tuebingen, Germany. 2 Department of Radiation Oncology, LMU Univerityhospital Munich, Munich, Germany. 3 Department of Medical Oncology and Pneumology (Internal Medicine VIII), UKT Universityhospital Tuebingen, Tuebingen, Germany. 4 Department for Radiotherapy, Die Radiologie, Munich, Germany Purpose/Objective: We compared patterns of failure in patients treated with chemoradiotherapy (CRT) alone vs. CRT and sequential and/or concurrent Programmed Cell Death 1 (PD-1) or Ligand 1 (PD-L1) immune checkpoint inhibition (IO, immuno oncology therapy) for inoperable stage III NSCLC