ESTRO 2025 - Abstract Book

S1352

Clinical - Lung

ESTRO 2025

Conclusion: The study addresses a first-order distinction between irradiation of the blood and mediastinal tissue containing lymph nodes. Both multivariable models have residual variance necessitating further refinement. Modeling results using D mean,med do not disregard the hypothesis and suggest to further analysis including other mediastinal tissue dose-volume metrics in EoRT ALC prediction and, ultimately, in OS prediction together with other clinical variables.

Keywords: NSCLC, lymphocytes, lymph nodes

References: 1. Jin JY, Hu C, Xiao Y, et al . Higher radiation dose to immune system is correlated with poorer survival in patients with stage III non-small cell lunh cancer: A secondary study of a phase 3 cooperative group trial (NRG Oncology RTOG 0617). Int J Radiation Oncol Biol Phys 2017;99:S151-S152. 2. Ladbury CJ, Rusthoven CG, Ross Camidge D, et al . Impact of radiation dose to the host immune system on tumor control and survival for stage III non-small cell lung cancer treated with definitive radiation therapy. Int J Radiation Oncol Biol Phys 2019;105:346-355.

2398

Digital Poster Third-Generation EGFR-TKIs Plus Thoracic Radiotherapy Improves Survival in Patients with EGFR-Mutated Stage IV Non-Small Cell Lung Cancer Xinhang Gu, Jiaxiao Geng, Hongfu Sun, Baosheng Li Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan,Shandong, China