ESTRO 2025 - Abstract Book

S1369

Clinical - Lung

ESTRO 2025

Repeating the PET/CT scans was significantly associated with changes in N-stage (p = 0.001) and overall TNM stage (p = 0.002). T -and M stages were not significantly changed with time interval (p = 0.705 and p = 0.180).

Conclusion: Repeating Quadra whole-body PET/CT scans with median imaging intervals of 8 weeks significantly changed the TNM staging for the majority of NSCLC patients. The TNM stage increases were primarily due to the identification of new nodal involvement. This suggests that timely PET/CT imaging prevents off-target treatment and ultimately leads to better treatment outcomes. Besides progression over time, these findings may be partly contributed to the increased sensitivity of the new Quadra PET/CT scanner.

Keywords: NSCLC, PET/CT, Staging

References: Nestle, U. et al. (2018). ESTRO ACROP guidelines for target volume definition in the treatment of locally advanced non-small cell lung cancer. Radiotherapy and Oncology , 127 (1), 1–5. https://doi.org/10.1016/j.radonc.2018.02.023

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Digital Poster AI driven multimodal signature to predict overall survival in stage III NSCLC receiving chemoradiation Edy Ippolito 1,2 , Carlo Greco 1,2 , Valerio Guarrasi 3 , Claudia Tacconi 2 , Camillo Maria Caruso 3 , Rosa Sicilia 4 , Michele Fiore 1,2 , Ermanno Cordelli 3 , Paolo Soda 5,6 , Sara Ramella 1,2 1 Radiation Oncology, Fondazione Policlinico Universitario Campus Biomedico, Rome, Italy. 2 Research Unit Radiation Oncology, Università Campus Bio-Medico, Rome, Italy. 3 Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico, Rome, Italy. 4 Dept. of Engineering, Università Campus Bio-Medico, Roma, Italy. 5 a Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico, Rome, Italy. 6 Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden