ESTRO 2025 - Abstract Book

S1436

Clinical - Lung

ESTRO 2025

Conclusion: Thoracic re-irradiation is a safe and effective treatment for patients experiencing locoregional failure after an initial course of RT. Further studies are necessary to optimize dose selection and treatment strategies.

Keywords: Reirradiation

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Digital Poster Surgery vs. chemoradiotherapy in early limited-stage small cell lung cancer (T1-2N0M0): A SEER-based database analysis Abdelrahman M Masheh 1 , Ahmed Salem 2,3 , Fanar Al-Samarat 4 , Malak Qasem 1 , Anas Althebyan 1 1 Faculty of Medicine, The Hashemite University, Zarqa, Jordan. 2 Department of Anatomy, Physiology and Biochemistry, Faculty of Medicine, The Hashemite University, Zarqa, Jordan. 3 Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. 4 Faculty of medicine, The Hashemite University, Zarqa, Jordan Purpose/Objective: Small cell lung cancer (SCLC) constitutes 13% of lung cancers, with 40% diagnosed as limited-stage (LS-SCLC). Early LS-SCLC (T1-2N0M0) represents 5% of SCLC cases. Guidelines recommend surgery followed by chemotherapy for early LS-SCLC, with chemoradiotherapy as an alternative treatment for comorbid patients. However, evidence for both treatments is limited, and the optimal therapeutic approach is debatable. This study investigated survival outcomes of early LS-SCLC patients treated with surgery or chemoradiotherapy using the SEER database. Material/Methods: We included patients aged ≥20 years with early LS-SCLC (T1-2N0M0) diagnosed between 2004 and 2021 in the SEER database, with complete clinical and therapeutic data. Patients were divided into two groups: surgery (with or without adjuvant chemotherapy) and chemoradiotherapy (external beam radiation and chemotherapy). We also