ESTRO 2025 - Abstract Book

S1461

Clinical – Mixed sites & palliation

ESTRO 2025

Conclusion: A novel technique termed 'PABR' administers a highly centralised ablative dose (50Gy in 5 fractions), while delivering low and safe palliative dose (20Gy in 5 fractions) to the peripheral regions of tumours. PABR approach is widely accessible and can be readily implemented in a routine clinical setting for prospective clinical trials to address a pressing need for the challenging palliative patient cohort.

Keywords: Spatial fractionation,partial ablation,bulky tumor

References: [1] Yu KK, Yeo A, Ngan S, Chu J, Chang D, Siva S, Wong A, Kron T, Hardcastle N, Gaudreault M, Chesson T, Williams S, Burns M, Chander S. Partially Ablative Body Radiotherapy (PABR): A novel approach for palliative radiotherapy of locally advanced bulky unresectable sarcomas. Radiother Oncol. 2024 May;194:110185. https://doi.org/10.1016/j.radonc.2024.110185 [2] Yu KK, Yeo A, Ngan S, Chu J, Chang D, Siva S, Wong A, Kron T, Hardcastle N, Gaudreault M, Chesson T, Williams S, Burns M, Chander S. Lettre to Editors: Partially Ablative Body Radiotherapy (PABR): A novel approach for palliative radiotherapy of locally advanced bulky unresectable sarcomas. Radiother Oncol. 2024 Aug;197:110275. https://doi.org/10.1016/j.radonc.2024.110275