ESTRO 2025 - Abstract Book

S1626

Clinical – äediatric tumours

ESTRO 2025

Conclusion: The dose threshold of 20 Gy RBE to the hypothalamus and 30 Gy RBE to the pituitary gland seems to be appropriate to predict GHD. Deficits seem to occur early after RT. Therefore, timely paediatric endocrinology consultation is necessary.

Keywords: Endocrinopathy, proton beam therapy, paediatrics

References: [1] Vatner RE et al. Endocrine Deficiency As a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients With Brain Tumors. J Clin Oncol. 2018 Oct 1;36(28):2854-2862. [2] Scoccianti S et al. Organs at risk in the brain and their dose-constraints in adults and in children: a radiation oncologist's guide for delineation in everyday practice. Radiother Oncol. 2015 Feb;114(2):230-8. [3] Darzy KH, Shalet SM. Hypopituitarism following Radiotherapy Revisited. Endocr Dev. 2009;15:1-24. [4] Chemaitilly W et al. Anterior hypopituitarism in adult survivors of childhood cancers treated with cranial radiotherapy: a report from the St Jude Lifetime Cohort study. J Clin Oncol. 2015 Feb 10;33(5):492-500.

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Digital Poster Re-Irradiation for recurrent pediatric CNS tumors: Insights into survival, toxicity, and symptom control. Sara Estrella-Márquez, Óscar Muñoz-Muñoz, Eva M Tejada-Ortigosa, Blas D Delgado-León, Jose L López-Guerra, Patricia Cabrera-Roldán Radiation Oncology, Virgen del Rocío University Hospital, Sevilla, Spain