ESTRO 2025 - Abstract Book

S1634

Clinical – äediatric tumours

ESTRO 2025

Conclusion: The efficacy of PBT for ICGCT at KPC was comparable to the previous reports. In addition, the results so far also showed favorable safety profiles. This is the largest study of PBT for ICGCT in pediatric and AYA patients to our knowledge.

Keywords: proton beam therapy, CNS, germ cell tumor

References: 1. MacDonald S. M., Trofimov A, Safai S, et al. Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes. Int J Radiat Oncol Biol Phys. 2011;79(1):121-9. 2. Hong K. T., Lee D. H., Kim B. K., et al. Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients. 2020 3. Baldo G. D., Vennarini S, Toniutti M, et al. Unraveling the impact of upfront chemotherapy and proton beam therapy on treatment outcome and follow-up in central nervous system germ cell tumors: a single center experience. Front Oncol. 2023 Oct 4:13:1259403

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