ESTRO 2025 - Abstract Book

S1666

Clinical - Sarcoma & skin cancer & malignant melanoma

ESTRO 2025

953

Digital Poster Overall survival in non-head and neck skin cancer patients with regional recurrence Aniwat Berpan Radiology, Vajira Hospital, Bangkok, Thailand

Purpose/Objective: To compare overall survival (OS) between patients with and without regional recurrence (RR).

Material/Methods: Data of patients with non-head and neck non-melanoma skin cancer were retrospectively collected, including age, sex, performance status, smoking history, immunosuppression, pathology, grade, tumor location, primary tumor status, nodal status, primary treatment, regional management and RR. Basal cell carcinoma was excluded. Associations between variables and time to death were analyzed using Cox proportional hazard regression. Results: A total of 62 patients and 77 lesions were identified. Median follow-up time was 4.1 years. Mean age was 66 years (SD 14.3). 93.5% had squamous cell carcinoma. Lesions located more commonly on extremities (61%) than trunk. Invasion beyond subcutaneous tissue was found in 11.7%. Six lesions presented with pathologic node involvement. Regional management was performed in 14 lesions. 26% developed RR. Salvage treatment including surgery and radiotherapy were done in 50% and 15%. Median time from treatment initiation to RR was 6.3 months (ranging from 2 to 36.7 months). 15.4 months was median time from RR to death. RR resulted in 5-year OS of 12.3% (median OS 2.3 years), while 5-year OS of patients without RR was 63.9% (median OS 8.5 years) (p-value <0.001) (Figure 1). In multivariable analysis, significant independent factors included tumor location, depth of invasion, regional involvement and regional recurrence, (HR 0.22; 95%CI 0.05-0.91, HR 11.26; 95%CI 2-63.47, HR 16.75; 95%CI 1.2 233.25 and HR 2.99; 95%CI 1.07-8.35) (Table 1). Figure 1. Overall survival between patients who developed and did not develop regional recurrence