ESTRO 2025 - Abstract Book

S1722

Clinical - Sarcoma & skin cancer & malignant melanoma

ESTRO 2025

Conclusion: To our knowledge, this is the first time that MCT dose-volume constraints were derived for STSE. In the future, we plan to increase the validation cohort and reduce the imbalance observed in the two cohorts, particularly in technique. For now, the use of a Dmax constraint can reduce the risk of grade 2+ STF for post-operative RT delivered to 60 or 66Gy.

Keywords: Extremity sarcoma; normal tissue sparing

References: 1.Seddon, B. et al. The IMRiS Trial: A Phase II Study of Intensity-Modulated Radiotherapy in Extremity Soft Tissue Sarcoma. Int. J. Radiat. Oncol. Biol. Phys. (2024) 2.Simões, R. et al. Toxicity, normal tissue and dose-volume planning parameters for radiotherapy in soft tissue sarcoma of the extremities: a systematic review of the literature. Radiother. Oncol. 109739 (2023) 3. Otter, S. et al. Evaluation of the Risk of Grade 3 Oral and Pharyngeal Dysphagia Using Atlas-Based Method and Multivariate Analyses of Individual Patient Dose Distributions Presented at the 54th Annual Meeting of the American Society for Radiation Oncology, Boston, MA, Oc. in International Journal of Radiation Oncology Biology Physics vol. 93 507–515 (2015).

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