ESTRO 2025 - Abstract Book

S1794

Clinical – Upper GI

ESTRO 2025

Conclusion: This study confirms our previously reported dosimetric advantages of CBCT-based oART in EC. We report high pCR (30.8%) and pMR (69.2%) rates compared to the literature (pCR rate 22% for AC) 2 with manageable toxicity following neoadjuvant oART in EC. Although no significant association between target dose parameters and treatment outcome was found in this cohort, the results suggest oART could improve treatment outcomes and may potentially support nonoperative strategies for selected patients.

Keywords: online adaptive radiotherapy, esophageal cancer

References: 1. Cone Beam Computed Tomography-Based Online Adaptive Radiation Therapy of Esophageal Cancer: First Clinical Experience and Dosimetri Benefits. Bachmann et al. Advances in Radiation Oncology, Volume 10, Issue 1, 101656, https://doi.org/10.1016/j.adro.2024.101656 2. Gaber CE, Sarker J, Abdelaziz AI, Okpara E, Lee TA, Klempner SJ, Nipp RD. Pathologic complete response in patients with esophageal cancer receiving neoadjuvant chemotherapy or chemoradiation: A systematic review and meta-analysis. Cancer Med. 2024 Feb;13(4):e7076. doi: 10.1002/cam4.7076. PMID: 38457244; PMCID: PMC10923050.