ESTRO 2025 - Abstract Book

S1906

Clinical - Urology

ESTRO 2025

Conclusion: This prospective randomized study showed that, when targeting the prostate and pelvis, the weekly 5-fraction SBRT yielded a similar rate of acute GU toxicities and a significantly lower rate of acute GI toxicities compared with fractionated IMRT. The once-weekly SBRT schedule appeared to be safe and favorable in terms of acute toxicity in HR-PC patients.

Keywords: SBRT, Prostate cancer, Randomized study

References: 1. Murthy V et al. Prostate-Only Versus Whole-Pelvic Radiation Therapy in High-Risk and Very High-Risk Prostate Cancer (POP-RT): Outcomes From Phase III Randomized Controlled Trial. J Clin Oncol. 2021;39(11):1234-1242. 2. Houlihan OA et al. A Randomized Feasibility Trial of Stereotactic Prostate Radiation Therapy With or Without Elective Nodal Irradiation in High-Risk Localized Prostate Cancer (SPORT Trial). Int J Radiat Oncol Biol Phys. 2023;117(3):594-609. 3. Glicksman RM et al. Elective pelvic nodal irradiation in the setting of ultrahypofractionated versus moderately hypofractionated and conventionally fractionated radiotherapy for prostate cancer: Outcomes from 3 prospective clinical trials. Clin Transl Radiat Oncol. 2024;49:100843