ESTRO 2025 - Abstract Book

S1969

Clinical - Urology

ESTRO 2025

ScRT20) were obtained by subtracting the CLAS values at T1 and T2 from the T0 values. A decrease of ≥2 points was considered clinically significant for RT-related fatigue onset.

Results:

1253 patients were evaluated. Median age was 72 years (range, 45-90). The vast majority (67%) had no or 1 comorbidity and 80% of patients had an optimal performance status (ECOG: 0). RT was performed as exclusive treatment in 61% of patients and the ADT was administered to 84% of patients. The treatment was administered using hypo-fractionated or stereotactic schedules in 86% of patients, while the remaining 14% received standard schedules. At T1, the RT-related fatigue onset (decrease of CLAS1, 2, and 3 values) was observed only in 10.8%, 14.3%, and 14.8% of the series. Similarly, at T2, the RT-related fatigue onset was observed only in 12.7%, 18.8% and 19.4% of patients. In the logistic regression analysis exploring factors contributing to the onset of RT-related fatigue, concomitant ADT, late toxicities, and alcohol consumption were significantly associated with an increase in RT related fatigue at T2 in CLAS3 (p<0.005). Furthermore, we observed a correlation between RT-related fatigue worsening of CLAS2 at T1 and acute genito-urinary toxicities (p:0.016). Other clinical variables increasing RT-related fatigue are reported in Table 1. Conclusion: In a large PC series mostly treated with modern techniques , RT-related fatigue onset was reported in <15% of patients. Treatment-related toxicities and factors unrelated to RT, such as alcohol assumption and concomitant ADT, play a significant role in fatigue onset.

Keywords: fatigue, prostate, quality of life

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Poster Discussion Association between prostate MRI PI-RADS classification and risk of Gleason upgrade during active surveillance: a systematic review and meta-analysis Shayan Smani 1 , Nishan Sohoni 1 , Marcin Miszczyk 2 , Tamás Fazekas 2 , Pawel Rajwa 2 , Alyssa Grimshaw 3 , Vinaik M Sundaresan 1 , Soum D Lokeshwar 1 , Jeffrey Weinreb 4 , Preston C Sprenkle 1 , Matthew R Cooperburg 5 , Tyler M Seibert 6 , William J Catalona 7 , Michael S Leapman 1 1 Department of Urology, Yale School of Medicine, New Haven, USA. 2 Department of Urology, Medical University of Vienna, Vienna, Austria. 3 Harvey Cushing/John Hay Whitney Medical Library, Yale School of Medicine, New Haven, USA. 4 Department of Radiology, Yale School of Medicine, New Haven, USA. 5 Department of Urology, University of California San Francisco School of Medicine, San Francisco, USA. 6 Department of Radiation Medicine, University of