ESTRO 2025 - Abstract Book

S1645

Clinical – äediatric tumours

ESTRO 2025

Summarising the level of FD across studies was challenging due to the large variation in outcome assessment methods (Fig 2A). In 3 studies, FD was compared to unirradiated controls, but comparisons were from limited sample size data and Caucasian populations. Possibly due to methodological variations and cohort differences, the proportion of children presenting with moderate to severe FD varied widely from 21-97% (Fig 2B).

Conclusion: This systematic review highlights the need for consensus on outcome measures, standardised grading systems, and diverse control data for dose-response study. Outcome measures should involve different levels of granularity for clinical reporting and dose-response analysis (where a standardised pipeline to extract 3D information is required).

Keywords: dentofacial, late effects, radiotherapy