ESTRO 2025 - Abstract Book

S1655

Clinical – äediatric tumours

ESTRO 2025

Emotional and behavioral assessments were conducted using the Child Behavior Checklist (CBCL) to identify internalizing (anxiety/depression, withdrawal, somatic complaints), externalizing (rule-breaking behavior, aggressive behaviors), and other problems (thought, social, attention problems). The Contagion, Empathy, and Cutoff (CEC) questionnaire focuses on the child's ability to recognize and replicate the emotions of others. Relationships between dosimetric data, specifically amygdala dose, and neuropsychological data were evaluated using Spearman's rank correlation coefficient and the Kruskal–Wallis test. Results: The analysis of data from 14 children showed that 70% of them received craniospinal irradiation. Treatment was multimodal in 100% of cases (surgery and/or chemotherapy and/or RT). The median time from completion of the questionnaires to the end of RT was 39,3 months (4,6 - 54 ). The median mean dose to the right and left amygdala was 31,4 Gy (5,1 – 41,9) and 28,9 Gy (2,7 – 41,9), respectively. The CBCL scores were subclinical or pathological, with internal, external, and total T-scores in 42,9%, 0%, and 28,6% of cases, respectively. The most pathological scores were related to anxiety, withdrawn, somatic complaints, social and thought problems. Nearly 30% of children obtained a subclinical T-score in attention problems. Patients scored higher in empathy compared to cutoff and contagion. No significant relationship was found with the dose received by the amygdala and these scores. However, a significant relationship was found between CBCL scores and doses to the brain, temporal lobes and cerebellum (p<0,05). Conclusion: Over 40% of the participants showed vulnerabilities or confirmed difficulties in emotional regulation particularly in anxiety/depression, withdrawal, somatic complaints, social problems, thought and attention problems. Pathological and subclinical CBCL scores were not significantly correlated with amygdala dose, but with doses to the brain, temporal lobes, and cerebellum. The analysis of the amygdala dose will be further studied within a multiparametric upcoming multicentric clinical trial including extended neurocognitive tests and analysis of the doses to multiple intracerebral organs at risks.

Keywords: cerebral amygdala, emotional regulation, children

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Digital Poster Long-Term Outcomes and Late Toxicities of Pediatric Nasopharyngeal Carcinoma Following Radiotherapy ikram el ochi Radiotherapy-Brachytherapy, Oncology Hospital, FES, Morocco

Purpose/Objective: To assess the long-term outcomes and late toxicities of radiotherapy in pediatric patients with NPC.

Material/Methods: Forty patients aged 9–17 years with histologically confirmed, non-disseminated NPC were retrospectively analyzed. The distribution of disease stages was as follows: stage I (2.9%), stage III (41.2%), and stage IV (55.9%). All patients underwent IMRT, receiving a prescribed dose of 70 Gy in 30 fractions to the nasopharyngeal target volume. Ninety percent of patients received induction chemotherapy followed by concurrent chemoradiotherapy, while 10% received only chemoradiotherapy Results: With a median follow-up of 48 months, local recurrence occurred in 1 patient (2.9%), while distant metastases were noted in 4 patients (11.8%), with 3 cases involving the lungs and 1 involving multiple organs. Five-year locoregional