ESTRO 2025 - Abstract Book

S1732

Clinical - Sarcoma & skin cancer & malignant melanoma

ESTRO 2025

4435

Digital Poster Radiotherapy for Keloids: Demographic and Clinical Factors Associated with Recurrence Claudia Laborda, Arantxa Campos, Claudia Colom, Ana Galan, María Cerrolaza, Cristina Garcia, Irene Carruesco, Blanca García, Sergio Lozares, Reyes Ibañez Radiotherapy, Hospital Universitario Miguel Servet, Zaragoza, Spain Purpose/Objective: Keloids are pathological scars characterized by excessive collagen deposition that extends beyond the original wound margins. Radiotherapy is a common adjunctive treatment to reduce recurrence after surgical excision. This study aims to evaluate demographic and clinical factors, particularly race, associated with keloid recurrence following radiotherapy. Material/Methods: A retrospective analysis was conducted on 53 patients treated with radiotherapy for keloids. Demographic variables (sex, age, race), treatment details (radiation dose, location), and clinical outcomes (recurrence) were recorded. Recurrence was defined as the reappearance of keloid growth during follow-up. Statistical analysis was performed using Jamovi V.2.3.28, considering a p-value <0.05 statically significant. Results: Of the 53 patients, 49% were female, and the median age was 33.88 years. Most patients were of European descent (56.6%), followed by African (18.87%), American (7.55%), and Arab (5.66%) ethnicities. The most common treatment location was the ear (62%). Radiation doses included primarily 16.5 Gy/5 Gy (71.7%). Recurrence was observed in 7 patients (13.2%) with a median follow up of 30.57 months, while 38 patients (71.7%) remained recurrence-free with a median follow-up of 51.6 months. Statistical analysis revealed no statistically significant association between race and recurrence (p = 0.270). However, patients of African descent exhibited a higher proportion of recurrence (25%) compared to other groups. Conclusion: The study found no statistically significant relationship between race and keloid recurrence after radiotherapy. Nonetheless, a higher recurrence rate was observed among patients of African descent. Radiotherapy remains an effective treatment option, as most patients achieved long-term recurrence-free outcomes. Future research should explore additional factors influencing recurrence, such as genetic predisposition, treatment protocols, and keloid size.

Keywords: Radiotherapy, treatment, keloids

References:

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