ESTRO 2025 - Abstract Book

S1734

Clinical - Sarcoma & skin cancer & malignant melanoma

ESTRO 2025

4540

Digital Poster Intraoperative radiotherapy in sarcomas: clinical analysis and outcomes

Maria Jordá 1 , Francisco Javier Celada 1 , Antonio Jose Conde Moreno 1 , Maria Ana Estornell 1 , Rodolfo Chicas 1 , Isaac Solero 1 , Maria Borrás 1 , Erika Paola Romero 1 , Yolanda Real 1 , Beatriz Geanina Cristea 1 , Emilio Nadal 1 , Paula Gonzalez 2 , Carolina de la Calva 3 , Julien Alcaide de Wandeleer 4 1 Radiation Oncology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 2 Clinical data management, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 3 Traumatology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 4 Medical physicist, Hospital Universitario y Politécnico La Fe, Valencia, Spain Purpose/Objective: Intraoperative radiotherapy (IORT) is an emerging therapeutic modality for sarcomas aimed at improving local disease control. This study analyzes the clinical outcomes of patients treated with IORT, focusing on its impact on tumor control and associated complications. Material/Methods: A retrospective analysis was conducted on patients diagnosed with sarcoma who received IORT at our center. The average age of the patients was 55.9 years. Tumor locations included the upper extremities, lower extremities, and retroperitoneum. Of the treated tumors, 35 were primary and 7 were recurrences. We recorded whether patients received external beam radiotherapy (EBRT) in addition to the intraoperative fraction and whether the EBRT was hypofractionated. Results: Of the 42 patients included, 33 received neoadjuvant EBRT, of which 9 were treated with hypofractionated EBRT. Surgical wound complications were observed in 21.4% of patients, with 24.2% in the conventional EBRT group and 11.1% in the hypofractionated group. During follow-up, with a median duration of 13 months, local tumor control was achieved in 80.9% of patients, with 53.8% in the retroperitoneal sarcoma group and 93.1% in the extremity sarcoma group. Conclusion: Intraoperative radiotherapy for sarcomas seems to be an effective strategy for improving local tumor control. These findings suggest the need for further studies to optimize the combination of IORT and EBRT in the treatment of sarcomas.

Keywords: IORT, sarcoma, local disease control