ESTRO 2025 - Abstract Book

S3869

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2025

Results:

A typical AFM of tumor patients is shown in Fig.1A. GM regions with warmer colors correspond to regions where FC patterns deviated from heathy controls. Several unique characteristics of tumor- and treatment-induced changes in rs-fMRI can be observed from APM. (1) Although different patients had different tumor locations (Fig.2A), disruptions in FC extended far beyond tumor regions (Fig.2B). Among all GM regions, disruptions in central and peripheral visual network and central sensorimotor network are common for most patients (>80%). (2) APM captured subject-specific FC changes (Figs.2C&D). Patients with tumors in similar brain regions could have quite different disruption patterns of brain connectivity and different cognitive performances. (3) Although not statistically significant yet (p=0.06), there was a consistent trend (Fig.1B) between longitudinal changes of global aberrancy score post-RT and NCF scores post RT. In this study, 19 and 13 patients had improved post-RT NCF (ΔNCF=11.2±10.4) and declined NCF ((ΔNCF=-9.8±6.7) scores respectively. Group-based frequency maps of aberrancy changes (Figs.2E&F) clearly showed that, for the NCF declining group, there were more brain regions (20% more) with increased FC abnormality post-RT (warm color) compared to those from the NCF-improved group.