ESTRO 2025 - Abstract Book

S410

Clinical - Biomarkers

ESTRO 2025

Conclusion: The ArteraAI-Prostate-Test significantly impacted shared ST-ADT decision-making, with >70% of patients who initially elected for ST-ADT ultimately avoiding it. The FIR/UIR split, although prognostic, did not predict for ST-ADT benefit. The lower absolute benefit for FIR men was incorporated into shared decision-making. This trial continues accrual to explore further shared decision-making, quality of life, toxicity reduction, cost-effectiveness, and efficacy.

Keywords: Artificial Intelligence, ADT, biomarker

References: 1. Jones CU, Pugh SL, Sandler HM, et al. Adding Short-Term Androgen Deprivation Therapy to Radiation Therapy in Men With Localized Prostate Cancer: Long-Term Update of the NRG/RTOG 9408 Randomized Clinical Trial. Int J Radiat Oncol Biol Phys . Feb 1 2022;112(2):294-303. doi:10.1016/j.ijrobp.2021.08.031 2. Nguyen PL, Je Y, Schutz FA, et al. Association of androgen deprivation therapy with cardiovascular death in patients with prostate cancer: a meta-analysis of randomized trials. JAMA . Dec 7 2011;306(21):2359-66. doi:10.1001/jama.2011.1745 3. Spratt DE, Tang S, Sun Y, et al. Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer. Res Sq . Apr 21 2023;doi:10.21203/rs.3.rs-2790858/v1

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Poster Discussion PROGNOSTIC ROLE OF PLASMA PROTEOMICS SIGNATURE IN OLIGORECURRENT PROSTATE CANCER PATIENTS UNDERGOING SBRT: RESULTS FROM A PROSPECTIVE TRIAL Ombretta Repetto 1 , Filippo Sperti 1 , Mariangela De Zorzi 1 , Giulia Brisotto 1 , Elena Muraro 1 , Matteo Turetta 1 , Fabio Del Ben 1 , Alessandra Donofrio 2 , Roberto Bortolus 2 , Martina Zanchetta 3 , Lucia Fratino 4 , Agostino Steffan 1 , Fabio Matrone 2 1 Immunopathology and Cancer Biomarkers Units, Department of Cancer Research and Advanced Diagnostics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. 2 Department of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. 3 Clinical Trial Office, Scientific Direction, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. 4 Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy