ESTRO 2025 - Abstract Book

S412

Clinical - Biomarkers

ESTRO 2025

Moreover, plasma protein profiles of polymetastatic-DP pts differed from those of no-DP pts due to the presence of 24 differentially abundant proteins, among which 2 were more abundant (CFHR5 and PZP) and 4 were less abundant (CDH5, HSPD1, PRDX2 and SOD3) in polymetastatic-DP versus no-DP. Conclusion: Overall, our work suggests that a plasma proteomics signature in orHSPC pts undergoing SBRT could be identified and used as prognostic indicator for BP- and DP-free survival. The occurrence of impaired vascular integrity (low CDH5 levels), a greater oxidative state (low PRDX2 levels) and an altered redox balance (low SOD3 levels) may correlate with the worsening of the analyzed outcomes. Interestingly, high PZP levels, associated with immunosuppressed status, correlate with a polymetastatic disease progression. The differential abundance of some selected proteins of interest will be validated by immunoblotting/Luminex assays. Further experiments will be performed by LC-MS/MS in a new cohort of patients. References: 1 Al-Daffaie FM, Al-Mudhafar SF, Alhomsi A, Tarazi H, Almehdi AM, El-Huneidi W, et al. Metabolomics and Proteomics in Prostate Cancer Research: Overview, Analytical Techniques, Data Analysis, and Recent Clinical Applications. Int J Mol Sci. 2024 May 7;25(10):5071. 2 Yan Y, Yeon SY, Qian C, You S, Yang W. On the Road to Accurate Protein Biomarkers in Prostate Cancer Diagnosis and Prognosis: Current Status and Future Advances. Int J Mol Sci. 2021 Dec 17;22(24):13537. 3 Feng K, Liu C, Wang W, Kong P, Tao Z, Liu W. Emerging proteins involved in castrationresistant prostate cancer via the ARdependent and ARindependent pathways (Review). Int J Oncol. 2023 Nov;63(5):127. Keywords: oligometastatic, prostate, proteins Digital Poster screening of clinical nutritional indicators influencing radiation enteritis associated with TNT in LARC Chenying Ma, Yi Fu, Shuyue Li, Jie Chen, Guanghui Gan, Juying Zhou Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China Purpose/Objective: To analyze the dose-effect relationships between clinical factors, dose-volume parameters, and radiation enteritis (RE) as well as severe acute radiation enteritis (SARE) associated with total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer, and to further identify clinical nutritional indicators that influence RE or SARE. Material/Methods: A total of 92 patients with rectal adenocarcinoma who received neoadjuvant therapy at the First Affiliated Hospital of Soochow University between January 2020 and September 2023 were included in the study. Clinical data and 1293