ESTRO 2025 - Abstract Book

S4211

RTT - Patient experience and quality of life

ESTRO 2025

Purpose/Objective: Quality of Life (QoL) is a critical aspect of care for elderly breast cancer survivors. The aim of this study was to assess QoL in elderly survivors of early-stage breast cancer, to investigate QoL differences based on clinical variables, and to identify the global QoL determinants. Material/Methods: Between January 2020 and June 2024, 250 elderly breast cancer patients (aged >65) were included in the study at the Radiotherapy Department of the National Institute of Oncology, Rabat, Morocco. All patients had at least 5 years of follow-up after surgery and were free of relapse. Participants may have received adjuvant radiotherapy, chemotherapy, and/or hormone therapy. QoL was assessed using the EORTC QLQ-C30 (general QoL), QLQ-BR45 (breast cancer-specific QoL), and QLQ-ELD14 (elderly-specific QoL) questionnaires. Demographic and clinical data were collected. Differences in QoL were analyzed based on surgery type (conservative vs. mastectomy) and the presence of limiting comorbidities using Wilcoxon tests. Univariate and multivariate logistic regression were performed to identify factors associated with low global QoL (≤50 points). Results: Of the 250 participants, 120 (48%) had limiting comorbidities. The mean Karnofsky score at baseline was 81 (SD 9.2). Among the patients, 208 (83%) received endocrine therapy. Most patients reported high QoL in functional areas (>80/100) and low symptoms (<20 points). Moderate limitations (>30 points) were found in concerns about others, joint stiffness (elderly-specific), sexual function and enjoyment (breast-specific). Light limitations (20-30 points) were observed in emotional functioning, fatigue, pain, and global QoL. Patients with limiting comorbidities showed lower QoL in multiple areas. There were no significant differences in QoL based on surgery type. Performance status, age, comorbidity, and specific QoL areas (functional, breast-specific, elderly-specific) were significantly associated with low global QoL. Fatigue and endocrine therapy symptoms had the highest R² (0.38). The best model explaining low global QoL included high fatigue, concerns about others, and endocrine therapy symptoms as risk factors, with an R² of 0.60. Conclusion: Elderly early-stage breast cancer patients adapted well to their disease and treatments. Comorbidity was a major determinant of QoL, while no significant differences were found between surgery groups. Fatigue, endocrine therapy side effects, and concerns about others were significant factors affecting global QoL.

Keywords: Breast Cancer , Quality of Life ,Comorbidity

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Digital Poster Satisfaction Among Cancer Patients Undergoing Radiotherapy: A Tunisian center experience Nadia Bouzid, Bochra Naija, Rym zanzouri, Imene Meddeb, Mouna Bakkali, Amal Chamsi, Ons Bettaieb, Dalia Yazid, Sabrine Tbessi, Samia Kanoun, Tebra Sameh Radiation Oncology, Farhat Hached Hospital, Sousse, Tunisia Purpose/Objective: Patient satisfaction and their positive perception toward the delivery of care improves the overall healthcare experience which can potentially lead to better treatment outcomes. Our aim is to highlight the most valued features in our department and identify unmet patient needs.