ESTRO 2025 - Abstract Book
S880
Clinical - Gynaecology
ESTRO 2025
Conclusion: This study highlights the significant correlation between bone marrow doses in the Total Pelvic Bone, lumbar spine, and iliac crest with acute hematologic toxicities, particularly thrombocytopenia, in patients receiving chemoradiation for locally advanced cervical cancer. These findings underscore the importance of optimizing radiation doses to minimize hematologic complications and improve patient outcomes.
Keywords: hematological toxicity, Marrow dosimetry, cervix
References: 1. Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340(15):1144–53. 2. Brixey CJ, Roeske JC, Lujan AE, Yamada SD, Rotmensch J, Mundt AJ. Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2002;54(5):1388– 96. 3. Rose BS, Liang Y, Lau SK, Jensen LG, Yashar CM, Hoh CK, et al. Correlation between radiation dose to (1)(8)F-FDG PET defined active bone marrow subregions and acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy. Int J Radiat Oncol Biol Phys.2012;83(4):1185–91
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