ESTRO 2025 - Abstract Book

S2044

Clinical - Urology

ESTRO 2025

Conclusion: The SABRE study is the largest randomized trial to date measuring the benefits of perirectal spacing compared to no spacing in prostate SBRT. Space creation using the iodinated PEG hydrogel aligns with prior studies of non-iodinated PEG hydrogel spacers (meta-analysis: median 10.8mm). 1 The reported separation with iodinated spacer supports the use of perirectal spacing in patients with intermediate risk prostate cancer. Long-term follow-up aims to provide insight into how space creation with this technology may reduce toxicity and be associated with improved quality of-life.

Keywords: Prostate cancer, hydrogel spacer, stereotactic RT

References: 1. Payne HA, Pinkawa M, Peedell C, Bhattacharya SK, Woodward E, Miller LE. SpaceOAR hydrogel spacer insertion prior to stereotactic body radiation therapy for men with localized prostate cancer: A systematic review. Medicine (Baltimore). 2021 Dec 10;100(49):e28111.

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Digital Poster Association between Lymphopenia and late patient-reported Intestinal Toxicity in Prostate Cancer Patients treated with whole-pelvis Radiotherapy Giuseppe Girelli 1 , Giuseppe Ricciardi 2 , Monica M. Vincenzi 2 , Barbara Avuzzi 3 , Domenico Cante 4 , Nadia G. Di Muzio 5,6 , Alessandro Magli 7 , Vittorio Vavassori 8 , Fernando Munoz 9 , Barbara N. Chiorda 10 , Maddalena Pavarini 2 , Luciana Rago 11 , Giuseppe Sanguineti 12 , Elisa Villa 13 , Justyna M. Waskiewiczr 14 , Roberta Carlevato 15 , Tiziana Rancati 16 , Claudio Fiorino 2 , Cesare Cozzarini 17 1 Radiotherapy, Ospedale degli Infermi, Biella, Italy. 2 Medical Physics, IRCCS San Raffaele Scientific Institute, Milano, Italy. 3 Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. 4 Radiotherapy, ASL TO4 Ospedale di Ivrea, Ivrea, Italy. 5 Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milano, Italy. 6 Radiotherapy, IRCCS San Raffaele Scientific Institute, Milano, Italy. 7 Radiotherapy, Azienda Ospedaliero Universitaria S. Maria della Misericordia, Udine, Italy. 8 Radiotherapy, Cliniche Gavazzeni-Humanitas,, Bergamo, Italy. 9 Radiation Oncology, Ospedale Regionale Parini- AUSL Valle d’Aosta, Aosta, Italy. 10 Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori,, Milano, Italy. 11 Radiotherapy, IRCCS Crob, Rionero in Vulture, Italy. 12 Radiation Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy. 13 Radiotherapy, Cliniche Gavazzeni-Humanitas, Bergamo, Italy. 14 Radiotherapy, Comprensorio Sanitario di Bolzano, Bolzano, Italy. 15 Radiation Oncology, Azienda Ospedaliera