ESTRO 2025 - Abstract Book

S2100

Clinical - Urology

ESTRO 2025

Conclusion: Radiation-induced lymphopenia, although prevalent in patients receiving pelvic irradiation, has no impact in overall survival or other negative outcomes. Influence of radiation techniques or pelvic volumes on the presence of lymphopenia showed a meaningful relationship. Further research may be needed to explore potential implications in the treatment of metastatic disease.

Keywords: lymphopenia, pelvic, radiation

References: - Baré M, et al. Lymphocyte-sparing pelvic radiotherapy for prostate cancer: An in-silico study. Phys Imaging Radiat Oncol. 2022 Jul 30;23:127-133. doi: 10.1016/j.phro.2022.07.006. - Cozzarini C, et al. Hematologic Toxicity in Patients Treated With Postprostatectomy Whole-Pelvis Irradiation With Different Intensity Modulated Radiation Therapy Techniques Is Not Negligible and Is Prolonged: Preliminary Results of a Longitudinal, Observational Study. Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):690-5. doi: 10.1016/j.ijrobp.2016.01.022. Epub 2016 Jan 28. - Schad MD, et al. Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer. Adv Radiat Oncol. 2019 Jan 25;4(2):323-330. doi: 10.1016/j.adro.2019.01.005.

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