ESTRO 2025 - Abstract Book

S2139

Clinical - Urology

ESTRO 2025

4481

Digital Poster The influence of prostate cancer treatment on geriatric conditions Katarzyna Paal, Bettina Stranz, Eva-Maria Thurner, Uwe Langsenlehner, Tanja Langsenlehner Radiooncology, Medical University, Graz, Austria

Purpose/Objective: Geriatric assessment (GA) tools can help to identify previously unrecognized conditions and may to help to predict whether aggressive cancer treatments will be tolerated and support therapeutic decisions in prostate cancer (PCa). However, little is known about the impact of PCa therapies including radiotherapy on functional outcome and on the development or acceleration of age-related chronic conditions. Thus, the aim of the present study was to analyze the influence of prostate cancer radiotherapy on the development or acceleration of aging-related clinical conditions measured by the tools of a comprehensive geriatric assessment. Material/Methods: A total of 314 prostate cancer aged ≥ 65 years treated with definitive radiotherapy were included in the present prospective study. All patients underwent a comprehensive geriatric assessment (CGA) prior to initiation of radiotherapy as well as 3 and 15 months after completion of radiotherapy. The GA tools comprised Mini Nutritional Assessment (MNA), Mental State Examination (MMSE), and the Geriatric Depression Scale (GDS). Functional status was assessed using the Activities of Daily Living (ADL) and the Instrumental Activities of Daily Living Scale (IADL) as well as the Timed Get-UP and Go-Test (TUG). Social situation was assessed using the Social status and support Survey (SOS), comorbidity was analyzed using the Charlson Comorbidity Index (CCI). Changes of geriatric conditions were analyzed using non-parametric tests for paired samples. Results: During the observation period, variance analysis revealed a significant increase in the results of the MMSE (p=0.002). Furthermore, a significant decrease in the results of the SOS was observed (p<0.001) suggesting a deterioration of the social situation. Variance analysis also showed a decrease in the results of the IADL indicating functional decline during the observation period (p=0.005). The results of the GDS significantly suggested a worsening of the mood (p<0.001). Furthermore, a significant difference in the results of the MNA was observed (p<0.001) with a significant decline in the results of the MNA at the first and second follow-up when compared to the baseline (p=0.001 and p<0.001, respectively). Conclusion: The results from our study indicate an adverse effect of cancer therapy on health domains measured with CGA tools. The underlying reasons for these findings are complex, however, the measurable alterations suggest that RT might contribute to the development or acceleration of aging-related conditions. References: Guida JL, Ahles TA, Belsky D, et al. Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. J Natl Cancer Inst 2019 Jul 18. Walter LC, Covinsky KE. Cancer screening in elderly patients: a framework for individualized decision making. JAMA 2001;285:2750 – 6. Monfardini S, Morlino S, Valdagni R, et al. Follow-up of elderly patients with urogenital cancers: Evaluation of geriatric care needs and related actions. J Geriatr Oncol 2017;8:289-95. Mohile SG, Dale W, Somerfield MR, et al. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology. J Clin Oncol 2018;36:2326-47. Keywords: aging, geriatric assessment, prostate cancer