ESTRO 2025 - Abstract Book

S2345

Interdisciplinary – Other

ESTRO 2025

Conclusion For the lower LET particles, the biological damage became independent of particle class when the cluster dose was calculated choosing F 4 as the preferred I p, evidencing the role of F 4 as a robust predictor of DSB foci. This result is in line with the findings of [2], where separation in survival fraction reached a minimum for F 5 and F 7 for aerobic and hypoxic cells, respectively.

Keywords: Cluster dose, DSB foci, nanodosimetry

References [1] G. Garty et al. , ‘First attempts at prediction of DNA strand-break yields using nanodosimetric data’, Radiat Prot Dosimetry , vol. 122, no. 1–4, pp. 451–454, 2006, doi: 10.1093/rpd/ncl515. [2] B. Faddegon et al. , ‘Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy’, Phys. Med. Biol. , vol. 68, no. 17, p. 175013, Aug. 2023, doi: 10.1088/1361-6560/acea16. [3] A. Belchior, J. F. Canhoto, U. Giesen, F. Langner, H. Rabus, and R. Schulte, ‘Repair Kinetics of DSB-Foci Induced by Proton and α-Particle Microbeams of Different Energies’, Life , vol. 12, no. 12, Art. no. 12, Dec. 2022, doi: 10.3390/life12122040.

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Digital Poster Examining 120 years of evolution of radiotherapy technology worldwide via quantitative patent analysis Flavio Jose 1 , Ariadna Bazaga Pozas 1 , Safir Doğa Kaya 1 , Geciane Porto 2 , Andrew Nisbet 1 1 Department of Medical Physics and Biomedical Engineering - Faculty of Engineering Sciences, University College London, London, United Kingdom. 2 Department of Business Administration - School of Economics, Administration and Accounting at Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil