ESTRO 2025 - Abstract Book

S2508

Physics - Autosegmentation

ESTRO 2025

congruent with synthetic situations. Both methods typically had higher/denser activations in more accurately auto contoured medial and anterior lobes (cyan). Curated models produced “cleaner" gradient class-activation mapping (GCAM) attributions. Quantitative analysis (Fig. 2) showed that PCλ 1 of guided GCAM’s (GGCAM) Euler characteristic profile had good predictive value of DSC for unseen AAPM cases, with AUROC=0.65, 0.74, 0.94, 0.81 for GBP, GCAM, GGCAM and PNet-A, respectively. For λ 1 <-1.8e3, 87% of cases were insufficient.