ESTRO 2025 - Abstract Book

S2717

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Figure 1. Planning challenge results of the automatically generated plan using Oncospace DVH predictions for optimization compared to all other submitted plans. A: Parotid_L D mean (27.4Gy-vs-30.9Gy [med] ); B: Parotid_R D mean (18.5Gy-vs.-19.9Gy [med] ); C: total points (132.4/150-vs.-130.7 [med] ); D: cord D max (25.2Gy-vs.-30.8 Gy [med] ).

Automatically generated plans for the institutional dataset achieved comparable target coverage, ΔD 99%-95% ≈0.46Gy (90%CI: [-1.8,3.3]Gy), with minimal increases in heterogeneity ΔD 2% (90%CI: [-2.4, 3.3]). For some OARs substantial reductions in D mean and D max were achieved in most patients. For example, for the parotids the average ΔD mean was -3.3Gy (90%CI: [-12.2,3.7]Gy) and for the spinal cord D max was lower by 11.6 Gy on average (90%CI: [-18.4,- 3.8]Gy). Additional metrics and OARs are shown in Figure 2.

Figure 2. Dose differences between automatically generated plans using DVH predictions and clinical plans for OARs (negative values indicate improved sparing) and targets.