ESTRO 2025 - Abstract Book

S2727

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

No significant correlations were observed between mean dose to regions of varying IGG and Fleiss' kappa between observer delineations, see Fig 2.

Conclusion: Our results indicate that challenges in intra-prostatic tumor delineation led to underdosage of actual tumor, mainly in lower-grade regions. Observer agreement did not correlate with dose coverage, making it a poor quality indicator.

Keywords: Hypofractionation, boost, histopathology

References: 1. Draulans C , et al. Stereotactic body radiotherapy with a focal boost to the intraprostatic tumor for intermediate and high risk prostate cancer: 5-year efficacy and toxicity in the hypo-FLAME trial. Radiotherapy and Oncology 201 , 110568 (2024).