ESTRO 2025 - Abstract Book

S2733

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Conclusion: Our investigation focused on advancing fVHEE-RT by addressing the need for progress in treatment planning strategies beside machine development. For the lung cases, fVHEE demonstrated potential for better sparing of OARs compared to VMAT, while maintaining target coverage. This was particularly evident for the case with multiple OARs close to the target. Another potential advantage was observed in the second lung case, with fVHEE enabling selective dose reductions for specific critical directions (e.g. spinal canal) compared to VMAT, while maintaining other dose parameters constant.

Acknowledgements Supported by Swiss Cancer Research Foundation (KFS-5948-08-2023).

Keywords: Very high energy electron, treatment planning

References: 1. Kokurewicz K, Brunetti E, Welsh GH, et al. Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. Sci Rep . 2019;9(1). doi:10.1038/s41598-019-46630-w 2. Whitmore L, Mackay RI, Van Herk M, Jones JK, Jones RM. Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications. Sci Rep . 2021;11:14013. doi:10.1038/s41598-021-93276-8