ESTRO 2025 - Abstract Book

S2737

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Conclusion: Optimizing VMAT plans for lymphocyte sparing allows further sparing lymphopenia-relevant organs with trade-offs in dose conformity and homogeneity, and potentially achieve moderate sparing lymphocytes for LA-NSCLC.

Keywords: Lymphopenia, Lymphocyte sparing, VMAT

References: [1] Miyazaki K, et al. Development of a lymphocyte count prediction model during chemoradiotherapy for lung cancer. Presented at the 36th Annual Meeting of the Japanese Society for Radiation Oncology (JASTRO); 2023; Tokyo, Japan. [2] Jin JY., et al. A framework for modeling radiation induced lymphopenia in radiotherapy. Radiotherapy and Oncology. 2020;144:105–13. https://doi.org/10.1016/j.radonc.2019.11.014.