ESTRO 2025 - Abstract Book

S2745

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

The DR_1.5 metric (Dmedian/Dose_STD), presented in Table 1, demonstrated values larger than those previously reported [2], attributed to a smaller dose standard deviation in our study, while maintaining similar Dmedian values. Conclusion: Four diamond geometric lattice layouts with vertex diameters as small as 0.7 and 1.0 cm were successfully planned using RapidArc for five large tumours cases. The newly proposed “Lattice Rating Index” offers a promising metric for comprehensive evaluation of heterogeneous “peaks-and-valleys” dose distributions within GTVs in LRT. References: [1] Wu, X., et al. (2020). The Technical and Clinical Implementation of LATTICE Radiation Therapy (LRT). Radiation research, 194(6), 737–746. [2] Kavanaugh, J. A. et al. (2022). LITE SABR M1: Planning design and dosimetric endpoints for a phase I trial of lattice SBRT. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology, 167, 172–178. [3] Gaudreault, M., et al. (2024). Development of an automated treatment planning approach for lattice radiation therapy. Medical physics, 51(1), 682–693. [4] Duriseti, S. et al. (2021). Spatially fractionated stereotactic body radiation therapy (Lattice) for large tumors. Advances in radiation oncology, 6(3), 100639. Keywords: Lattice RT, SFRT, Treatment planning metrics