ESTRO 2025 - Abstract Book

S2811

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Conclusion: A validated population-based pediatric breast model was developed for cohort-wide breast dose reconstruction. While not uncommon for dose uncertainties to reach 40% in studies when patient anatomy is unknown, our methodology resulted in reconstructed mean breast doses within 5% on average and dose-volume metrics within 10%. This model will be used to reconstruct pre-CT era breast doses for adolescent females in a multi-institutional cohort of childhood cancer survivors, providing more accurate dose-response models for clinical translation in contemporary radiotherapy. References: 1. Mulder RL, Hudson MM, Bhatia S, et al. Updated Breast Cancer Surveillance Recommendations for Female Survivors of Childhood, Adolescent, and Young Adult Cancer From the International Guideline Harmonization Group. J Clin Oncol . 2020;38(35):4194-4207. 2. Lee C, Lodwick D, Williams JL, Bolch WE. Hybrid computational phantoms of the 15 ‐ year male and female adolescent: Applications to CT organ dosimetry for patients of variable morphometry. Med Phys . 2008;35(6Part1):2366-2382. 3. Vũ Bezin J, Allodji RS, Mège JP, et al. A review of uncertainties in radiotherapy dose reconstruction and their impacts on dose–response relationships. J Radiol Prot . 2017;37(1):R1-R18. Keywords: subsequent breast cancer, dose reconstruction