ESTRO 2025 - Abstract Book

S2822

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Conclusion: Based on current understanding of the FLASH-effect and LQ-model, OARs at tumor sites with α/β T <≈ α/β NT seems to benefit from FLASH-hypofractionated treatment regimes. However, not all tumor sites may benefit from FLASH-RT given the variability in toxicity and NT-sparing.

Keywords: FLASH-Radiotherapy, Normal Tissue Sparing

References: [1] Böhlen TT, Germond JF, Bourhis J, Vozenin MC, Ozsahin EM, Bochud F, Bailat C, Moeckli R. Normal Tissue Sparing by FLASH as a Function of Single-Fraction Dose: A Quantitative Analysis. Int J Radiat Oncol Biol Phys. 2022 Dec 1;114(5):1032-1044. doi: 10.1016/j.ijrobp.2022.05.038. Epub 2022 Jul 8. PMID: 35810988.