ESTRO 2025 - Abstract Book

S2838

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Conclusion: This study systematically examined the differences in dose distributions between HNC patients treated with definitive photon and proton therapies. Using the biological dose in part mitigates OAR dose reduction between these two modalities, though significant dose reductions remain in OARs for protons. These OAR reductions may explain the reduced toxicity seen on randomized trial. However, increased biological dose, especially to the brachial plexus and mandible, should be considered.

Keywords: Head and neck cancer, definitive proton therapy

References: 1. Busse P, Rosenthal DI, Hernandez M, et al. Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC). Journal of Clinical Oncology . 2024;42:6006–6006.