ESTRO 2025 - Abstract Book

S2887

Physics - Dose prediction, optimisation and applications of photon and electron planning

ESTRO 2025

Conclusion: There remains a clear benefit in adding hyperthermia to radiotherapy, as well as from adding EQD RT optimization to conventional radiotherapy, even when considering the variability in EQD RT due to tissue-property uncertainties. The increased achievable range of temperature levels for more robust hyperthermia plans, combined with EQD RT optimization, results in an enhanced range of possible EQD RT levels. The resulting thermoradiotherapy treatment would likely have an increased combined effect, with less need for adjustments during treatment. Incorporating a model for tissue-property uncertainties allows to evaluate intra-patient variability in EQD RT terms, helpful for assessing feasibility and outcome of combined thermoradiotherapy treatment.

Keywords: Hyperthermia, EQD, Tissue-Property Uncertainties

References: 1. J. Ödén, K. Eriksson, B. Pavoni, J. Crezee, and H.P. Kok, “A novel framework for thermoradiotherapy treatment planning”. Int. J. Radiat. Oncol. Biol. Phys, vol 199(5), p. 1530-1544. 2. T. D. Herrera, J. Ödén, A. Lorenzo Polo, J. Crezee, and H. P. Kok, “Thermoradiotherapy Optimization Strategies Accounting for Hyperthermia Delivery Uncertainties”, Int. J. Radiat. Oncol. Biol. Phys., vol 120(5), p. 1435-1447, 2024. 3. J. A. Groen, J. Crezee, H. W. M. van Laarhoven, M. F. Bijlsma, and H. P. Kok, "Quantification of tissue property and perfusion uncertainties in hyperthermia treatment planning: Multianalysis using polynomial chaos expansion," Comput Methods Programs Biomed, vol. 240, p. 107675, 2023.