ESTRO 2025 - Abstract Book
S284
Brachytherapy - Gynaecology
ESTRO 2025
Conclusion: iRex60, ISV60, and D2cc rectum were failed to established correlation with grade >=2 GI toxicity. However, mean IR CTV volume (HR 1.14, p=0.02) and Sigmoid D0.1cc (HR 1.27, p=0.045) showed the potential correlation to further investigate for further GI toxicity control in addition to the robust optimization from EMBRACE-II protocol.
Keywords: ISV, indirect ratio of excess dose volume, GI tox
References: Prasartseree T, Dankulchai P, Hoskin PJ. Excess dose-related parameters (Vex, Rex, and iRex): novel predictors and late toxicity correlations in cervical cancer image-guided adaptive brachytherapy. J Contemp Brachytherapy . 2020;12(5):441-453. doi:10.5114/jcb.2020.100377 T. Prasartseree, P. Dankulchai, W. Sittiwong, K. Thephamongkhol. HYPOCx-iRex (TCTR20210812003) A Phase II RCT: 44 Gy/20F VS 45 Gy/25F CCRT in Cervical Cancer: Six-month Post-RT Update. International Journal of Radiation Oncology*Biology*PhysicsVolume 117, Issue 2, Supplement, 1 October 2023, Page S41, https://doi.org/10.1016/j.ijrobp.2023.06.313
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