ESTRO 2025 - Abstract Book

S2958

Physics - Image acquisition and processing

ESTRO 2025

Conclusion: This study demonstrates the feasibility to acquire online 12 N images at spot-level within sub-second time scales by a spot-delayed irradiation. The range uncertainty achieved is promising for implementing reduced margins in robust optimization. These findings represent a significant step towards the clinical translation of real-time range verification in proton therapy, with the aim to improve patient outcome.

Keywords: proton therapy, range verification

References: 1. Paganetti, H. Range uncertainties in proton therapy and the role of Monte Carlo Simulations Phys. Med. Biol. 57 R99-R117 (2012) 2. Lomax, A.J. Myths and realities of range uncertainty Br. J. Radiol. 93 20190582 (2020) 3. Ozoemelam, I. et al. Feasibility of quasi-prompt PET-based range verification in proton therapy. Phys. Med. Biol. 65 , 245013 (2020) 4. Zapien-Campos, B. et al. Measurement of the 12 C(p,n) 12 N reaction cross section below 150 MeV. Phys. Med. Biol. 69 , 075025 (2024) 5. Ahmadi Ganjeh, Z. et al. RayStation/GATE Monte Carlo simulation framework for in vivo verification of proton therapy based on the 12 N imaging. Phys. Med. Biol. 69 , 195007 (2024)

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