ESTRO 2025 - Abstract Book

S3012

Physics - Image acquisition and processing

ESTRO 2025

Keywords: CBCT, quantitative imaging, scatter suppression

2356

Proffered Paper 4DCBCT with clinical confidence in 63% less time and with 85% less dose: Results of the ADAPT clinical trial (NCT04070586). Owen Dillon 1 , Ben K.F. Lau 1 , Tess Reynolds 1 , Paul J Keall 1 , Vicky Chin 1,2 , Nabeeha Chowdhury 1 , Shalini K Vinod 2 , Jan Jakob Sonke 3 , Ricky T O'Brien 4 1 Image X, University of Sydney, Sydney, Australia. 2 Radiation Oncology, Ingham Institute for Applied Medical Research,, Sydney, Australia. 3 Adaptive Radiotherapy, Netherlands Cancer Institute, Amsterdam, Netherlands. 4 Medical Imaging Facility, Royal Melbourne Institute of Technology, Melbourne, Australia Purpose/Objective: Four Dimensional Cone Beam Computed Tomography (4DCBCT) is the recommended modality for lung cancer radiation therapy [1], however current scan protocols involve long imaging times (240 seconds) and significant imaging dose [2]. Adaptive 4DCBCT has been developed to enable fast low dose 4DCBCT on standard radiation therapy systems with the aim of reducing treatment time while improving patient safety and experience [3] while still delivering clinically acceptable images.

Material/Methods: The ADaptive CT Acquisition for Personalised Thoracic imaging (ADAPT) clinical trial (NCT04070586, ethics approval